Publications

Spolski R, Li P, Chandra V, Shin B, Goel S, Sakamoto K, Liu C, Oh J, Ren M, Enomoto Y, West EE, Christensen SM, Wan ECK, Ge M, Lin JX, Yan B, Kazemian M, Yu ZX, Nagao K, Vijayanand P, Rothenberg EV, Leonard WJ (2023). Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function. Science Immunology 8 (89) doi:10.1126/sciimmunol.adi8217.

Mihalik NE, Steinberger KJ, Stevens AM, Bobko AA, Hoblitzell EH, Tseytlin O, Akhter H, Dziadowicz SA, Wang L, O’Connell RC, Monaghan KL, Hu G, Mo X, Khramtsov VV, Tseytlin M, Driesschaert B, Wan ECK#, Eubank TD# (2023). Dose-specific intratumoral GM-CSF modulates breast tumor oxygenation and antitumor immunity. The Journal of Immunology 211: 1589-1604 doi:10.4049/jimmunol.2300326. (#Corresponding author)

Monaghan KL, Zheng W, Akhter H, Wang L, Ammer AG, Li P, Lin JX, Hu G, Leonard WJ, Wan ECK# (2023). Tetramerization of STAT5 regulates monocyte differentiation and the dextran sulfate sodium-induced colitis in mice. Frontiers in Immunology 14:1117828 doi:10.3389/fimmu.2023.1117828. (#Corresponding author)

Monaghan KL, Aesoph D, Ammer AG, Zheng W, Rahimpour S, Farris BY, Spinner CA, Li P, Lin JX, Yu ZX, Lazarevic V, Hu G, Leonard WJ#, Wan ECK# (2021). Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation. PNAS 118 (52) e2116256118 doi:10.1073/pnas.2116256118 (#Corresponding author)

Engler-Chiurazzi E, Monaghan KL, Wan ECK, Ren X (2020). Role of B cells and the aging brain in stroke recovery and treatment. GeroScience doi:10.1007/s11357-020-00242-9.

Monaghan KL*, Farris BY*, Zheng W, Wan ECK# (2020). Characterization of immune cells and proinflammatory mediators in the pulmonary environment. Journal of Visualized Experiments 160, e61359 doi:10.3791/61359. (*Co-first authorship; #Corresponding author)

Monaghan KL, Wan ECK# (2020). The role of granulocyte-macrophage colony-stimulating factor in murine models of multiple sclerosis. Cells 9:611 doi:10.3390/cells9030611. (#Corresponding author)

Yang J, Wang HX, Xie J, Li L, Wang J, Wan ECK, Zhong XP (2020). DGK a and z activities control TH1 and TH17 cell differentiation. Frontiers in Immunology 10:3048 doi:10.3389/fimmu.2019.03048.

Pan Y, Deng W, Xie J, Zhang S, Wan ECK, Li L, Tao H, Hu Z, Chen Y, Ma L, Gao J, Zhong XP (2020). Graded diacylglycerol kinases a and z activities ensure mucosal-associated invariant T cell development. European Journal of Immunology 50:192-204 doi:10.1002/eji.201948289.

Monaghan KL, Zheng W, Hu G#, Wan ECK# (2019). Monocytes and monocyte-derived antigen-presenting cells have distinct gene signatures in experimental model of multiple sclerosis. Frontiers in Immunology 10:2779 doi:10.3389/fimmu.2019.02779. (#Corresponding author)

Farris BY, Monaghan KL, Zheng W, Amend CD, Hu H, Ammer AG, Coad JE, Ren X, Wan ECK# (2019). Ischemic stroke alters immune cell niche and chemokine profile in mice independent of spontaneous bacterial infection. Immunity, Inflammation and Disease 7:326-341 doi:10.1002/iid3.277. (#Corresponding author)

Palle P*, Monaghan KL*, Milne SM, Wan ECK# (2017). Cytokine signaling in multiple sclerosis and its therapeutic applications. Medical Sciences 5:23 doi:10.3390/medsci5040023. (*Co-first authorship; #Corresponding author)

Prior to WVU

Leonard WJ and Wan CK (2016). IL-21 signaling in immunity. F1000 Research 5:224 doi:10.12688/f1000research.7634.1.

Wan CK*, He C*, Sun L, Egwuagu CE, Leonard WJ (2016). Cutting Edge: IL-1 receptor signaling is critical for the development of autoimmune uveitis. Journal of Immunology 196:543-546. (*Co-first authorship)

Wan CK, Li P, Spolski R, Oh J, Andraski AB, Du N, Yu ZX, Dillon CP, Green DR, Leonard WJ (2015). IL-21-mediated non-canonical pathway for IL-1b production in conventional dendritic cells. Nature Communications 6:7988 doi: 10.1038/ncomms8988.

Wan CK*, Andraski AB*, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA II, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ (2015). Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells. PNAS 112:9394-9399. (*Co-first authorship)

Wan CK, Oh J, Li P, West EE, Wong EA, Andraski AB, Spolski R, Yu ZX, He J, Kelsall BL, Leonard WJ (2013). The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity 38:514-527.

Spolski R, Wang L, Wan CK, Bonville CA, Domachowske JB, Kim HP, Leonard WJ (2012). IL-21 promotes the pathologic immune response to pneumovirus infection. Journal of Immunology 188:1924-1932.

Gorentla BK, Wan CK, Zhong XP (2011). Negative regulation of mTOR activation by diacylglycerol kinases. Blood 117:4022-4031.

Kulis M, Wan CK, Gorentla BK, Burks AW, Zhong XP (2011). Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity. Journal of Allergy and Clinical Immunology 128:212-214.

Wan CK, Tse AK, Yu ZL, Zhu GY, Wang H, Fong DW (2010). Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis. Phytomedicine 17: 702-705.

Tse AK, Zhu GY, Wan CK, Shen XL, Yu ZL, Fong WF (2010). 1alpha,25-Dihydroxyvitamin D(3) inhibits transcriptional potential of nuclear factor kappa B in breast cancer cells. Molecular Immunology 47: 1728-1738.

Zhong XP, Guo R, Zhou H, Liu C, Wan CK (2008). Diacylglycerol kinases in immune cell function and self-tolerance. Immunological Reviews 224:249-264.

Guo R*, Wan CK*, Carpenter JH, Mousallem T, Boustany RN, Kuan CT, Burks AW, Zhong XP (2008). Synergistic control of T cell development and tumor suppression by diacylglycerol kinase α and ζ. PNAS 105: 11909-11914. (*Co-first authorship)

Tse AK, Wan CK, Shen XL, Zhu GY, Cheung HY, Yang M, Fong WF (2007). 1,25-Dihydroxyvitamin D(3) induces biphasic NF-kappaB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IkappaB. Experimental Cell Research 313:1722-1734.

Fong WF, Wan CK, Chu GY, Chattopadhyay A, Dey S, Zhao Z, Shen XL (2007). Schisandrol A from Schisandra chinensis reverses P-glycoprotein-mediated multidrug resistance by affecting Pgp-substrate complexes. Planta Medica 73:212-220.

Tse AK, Wan CK, Zhu GY, Shen XL, Cheung HY, Yang M, Fong WF (2007). Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation. Molecular Immunology 44:2647-2658.

Chan KF, Yum EHW, Wan CK, Fong WF, Yu KN (2007). Feasibility study on the use of polyallyldiglycol-carbonate cell dishes in TUNEL assay for alpha-particle radiobiological experiments. Nuclear Instruments and Methods in Physics Research Journal B 262:128-134.

Wan CK, Wang C, Cheung HY, Yang M, Fong WF (2006). Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells. Cancer Letters 241: 31-41.

Wan CK, Chu GY, Shen XL, Chattopadhyay A, Dey S, Fong WF (2006). Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells. Biochemical Pharmacology 72:824-837.

Tse AK, Wan CK, Shen XL, Yang M, Fong WF (2005). Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation. Biochemical Pharmacology 70:1443-1457.

Wang C, Zhang JX, Shen XL, Wan CK, Tse AK, Fong WF (2004). Reversal of P-glycoprotein-mediated multidrug resistance by Alisol B 23-acetate. Biochemical Pharmacology 68:843-855.

Poon KH, Zhang J, Wang C, Tse AK, Wan CK, Fong WF (2004). Betulinic acid enhances 1alpha,25-dihydroxyvitamin D3-induced differentiation in human HL-60 promyelocytic leukemia cells. Anticancer Drugs 15:619-624.