Neuro-immune Crosstalk in CNS Diseases
About us
The Wan lab was established at West Virginia University School of Medicine, Morgantown, West Virginia in 2016. The overarching goal of the research group is to understand how the activation of immune system impacts the progression of neurological diseases, with current focuses on multiple sclerosis and ischemic stroke. Specifically, we are interested in identifying signaling pathways and mediators that determine the detrimental vs. beneficial effects of immune cells on the progression of neurological diseases, with the ultimate goal to develop targeted therapeutic strategies. We use animal models, cell cultures, flow cytometry, next-generation sequencing, and cutting-edge imaging techniques to address our scientific questions.
Lab News
Sep 2024
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Paul Owolabi joined our lab for his second PhD rotation. Welcome, Paul!
Aug 2024
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Mahta Abbaspour joined our lab for her first PhD rotation. Welcome, Mahta!
July 2024
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Our work has been featured in WVUToday! article link
May 2024
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We welcome Evita Yang joining our lab as biology technician!
Mar 2024
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We welcome Nic Fitzgerald joining our lab as biology technician!
Jan 2024
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The lab received our first R01 award from NIAID to study the role of STAT5 tetramerization in neuroinflammation. Project details
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Ava Warner and Zayla Steen joined the lab as undergraduate researcher. Welcome, Ava and Zayla!
Nov 2023
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Collaborative work with Dr. Warren Leonard studying the role of super-enhancer elements in controlling the cell type-specific regulation of CD25 function has been published in Science Immunology. article link
Sep 2023​
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Collaborative work with Dr. Tim Eubank studying dose-specific GM-CSF effect on breast cancer immunity has been published in The Journal of Immunology. article link
May 2023
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Sumehra Amin joined the lab as a summer undergraduate intern. Welcome Sumehra!
April 2023
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Our work on the role of STAT5 tetramers in regulating monocyte differentiation and colon pathogenesis in an animal model of colitis has been published in Frontiers in Immunology. article link
Feb 2023
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Kody is awarded WVU IMMB Research Internship to support his research for the next two years. Congratulations!
Jan 2023
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The lab received a two-year award from NIGMS/WV-INBRE program to study the role of cellular metabolism in multiple sclerosis fatigue.
Nov 2022
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Kelly moved to NIH to continue her postdoctoral training. Good luck, Kelly!
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Linda won the best poster award at Autumn Immunology Conference. Congratulations!
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Lillian Shields joined the lab as an undergraduate researcher. Welcome, Lily!
Oct 2022
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Kody Moore joined the lab as an undergraduate researcher. Welcome, Kody!
Aug 2022​
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Linda won the best poster award in the 2022 Summer Undergraduate Research Symposium. Congratulations!
Jun 2022
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The lab received a one-year R56 award from NIAID to study the role of STAT5 tetramerization in neuroinflammation. project details
Apr 2022
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Kelly successfully defended her dissertation. Congratulations, Dr. Monaghan!
Mar 2022
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Kelly's paper has been featured in WVUTODAY. article link
Jan 2022
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The lab received a two-year R21 award from NINDS to study the role of CD11c+ microglia in stroke recovery. project details
Dec 2021
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Kelly's work on the pathogenic role of STAT5 tetramerization in EAE has been published in PNAS. article link
Where we are
West Virginia University School of Medicine
64 Medical Center Drive, 2079 HSN
Morgantown, WV 26506
